Murine fetal natural killer cells are functionally and structurally distinct from adult natural killer cells
نویسندگان
چکیده
منابع مشابه
Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells.
Intercellular transfer of proteins across the immunological synapse is emerging as a common outcome of immune surveillance. We previously reported that target-cell MHC class I protein transfers onto natural killer (NK) cells expressing cognate killer Ig-like receptors (KIRs). We now show that, for both murine and human cells, target cells expressing inhibitory MHC class I ligands acquire cognat...
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Natural killer (NK) cells express C-type lectin-like receptors, encoded in the NK gene complex, that interact with major histocompatibility complex class I and either inhibit or activate functional activity. Human NK cells express heterodimers consisting of CD94 and NKG2 family molecules, whereas murine NK cells express homodimers belonging to the Ly-49 family. The corresponding orthologues for...
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What do they do? NK cells are equipped with cytotoxic granules that contain the arsenal of cytotoxic molecules used in killing virally infected and cancerous cells. They recognize their targets, in part, by means of activating signals that are only just beginning to be identified, but also by detecting cells that are deficient in cell-surface class I molecules of the major histocompatibility co...
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The Src homology (SH) 2/SH3 domain-containing protein Grb2 and the oncoprotein Shc have been implicated in a highly conserved mechanism that regulates p21 ras activation. We investigated the involvement of these adaptor proteins in the signaling pathway induced by CD16 or interleukin (IL) 2R triggering in human natural killer (NK) cells. Both p46 and p52 forms of Shc were rapidly and transientl...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 1999
ISSN: 0741-5400
DOI: 10.1002/jlb.66.4.625